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Bioinformatics Advance Access originally published online on January 28, 2009
Bioinformatics 2009 25(5):680-681; doi:10.1093/bioinformatics/btp045
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

QMSim: a large-scale genome simulator for livestock

Mehdi Sargolzaei * and Flavio S Schenkel

Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada

*To whom correspondence should be addressed.


  Abstract

Summary: QMSim was designed to simulate large-scale genotyping data in multiple and complex livestock pedigrees. The simulation is basically carried out in two steps. In the first step, a historical population is simulated to establish mutation-drift equilibrium, and in the second step, recent population structures are generated, which can be very complex. A wide variety of genome architectures, ranging from infinitesimal model to single-locus model, can be simulated. The program is efficient in terms of computing time and memory requirements.

Availability: Executable versions of QMSim for Windows and Linux are freely available at http://www.aps.uoguelph.ca/~msargol/qmsim/.

Contact: msargol{at}uoguelph.ca

Associate Editor: Alex Bateman

Received on November 17, 2008; revised on January 15, 2009; accepted on January 18, 2009

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