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Bioinformatics Advance Access originally published online on February 27, 2009
Bioinformatics 2009 25(9):1192-1194; doi:10.1093/bioinformatics/btp116
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

WSsas: a web service for the annotation of functional residues through structural homologues

David Talavera *,{dagger}, Roman A. Laskowski and Janet M. Thornton

EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

*To whom correspondence should be addressed.


  Abstract

Motivation: Annotation tools help scientists to traverse the gap between characterized and uncharacterized proteins. Tools for the prediction of protein function include those which predict the function of entire proteins or complexes, those annotating functional domains and those which predict specific residues within the domain. We have developed WSsas, a web service focused on the annotation of essential functional residues. WSsas uses similarity searches and pairwise alignments to transfer functional information about binding, catalytic and protein–protein interaction residues from solved structures to query sequences. In addition, WSsas can supply information about the relevant functional atoms. The web service definition (WSDL) file and a Perl client are freely available at http://www.ebi.ac.uk/thornton-srv/databases/WSsas/.

Contact: talavera{at}ebi.ac.uk

{dagger}Present address: Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

Associate Editor: Burkhard Rost

Received on November 24, 2008; revised on February 9, 2009; accepted on February 23, 2009

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