Skip Navigation

This Article
Right arrow Full Text (Print PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by lida, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by lida, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1987 IRL Press Ltd.

DNA sequences and multivariate statistical analysis. Categorical discrimination approach to 5’ splice site signals of mRNA precursors in higher eukaryotes' genes

Yôichi lida

Department of Chemistry, Faculty of Science, Hokkaido University Sapporo 060, Japan

The signals which direct excision of introns from mRNA precursors in higher eukaryotes' genes are not well understood. Although a consensus sequence,CAAG/GTAGAGT, has been proposed with the 5’ splice site, actual 5’ splice site sequences differ from it to a greater or lesser degree. In order to study such a signal more quantitatively, nucleotide sequences were transformed into categorical data, and multivariate statistical analysis was applied to such a system. Categorical weights on the variables were estimated in such a way that the two classes of 5’ splice site sequences and sequences other than 5’ splice site might be discriminated most distinctly. The 5’ splice site signals were then characterized in terms of those statistical results.

Received on November 6, 1986; accepted on February 17, 1987

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.