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© 1987 IRL Press Ltd.

Molecular approaches to genome analysis: a strategy for the construction of ordered overlapping clone libraries

Frank Michiels , Alister G. Craig , Guenther Zehetner , George P. Smith 1 and Hans Lehrach *,2

European Molecular Biology Laboratory, Postfach 102209 D-6900 Heidelberg, FRG
1Division of Biological Sciences, Tucker Hall, University of Missouri Columbia, MO 65211, USA

*To whom reprint requests should be sent

Here we describe progress on a series of molecular techniques designed to bridge the gap between genetic and molecular distances in mammals. This is an essential step in the molecular cloning of genes defined by mammalian mutations, and in the molecular analysis of large regions of mammalian genomes. We summarize approaches for the physical and molecular analysis of genetic distances and describe the experimental, statistical and computational basis of a new approach to create ordered libraries of overlapping clones from large genomes.

Received on December 30, 1986; accepted on May 12, 1987

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