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© 1988 IRL Press Ltd

Software for genome mapping by fingerprinting techniques

John Sulston *, Frank Mallett , Rodger Staden , Richard Durbin , Terry Horsnell and Alan Coulson

MRC Laboratory of Molecular Biology Hills Road, Cambridge, CB2 2QH, UK

*To whom reprint requests should be sent

A genome mapping package has been developed for reading and assembling data from clones analysed by restriction enzyme fragmentation and polyacrylamide gel electrophoresis. The package comprises: data entry; matching; assembly; statistical analysis; modelling. Data entry can be either manual or by a semiautomatic system based on a scanning densitometer. The primary emphasis in the analytical routines is on flexibility and interactive convenience, so that the operator has full knowledge of and control over the growing map, but a variety of automatic options are included. The package continually grows to meet the needs of the Caenorhabditis project.

Received on July 17, 1987; accepted on November 20, 1987

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