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© 1988 IRL Press Ltd

Reiterative RNA folding and occupancy rate analysis for mRNA modelling

Joseph L. Modelevsky * and Thomas G. Akers

Pitman-Moore, Inc. 1810 Frontage Road, Northbrook, IL 60062, USA

*To whom reprint requests should be sent at Digital Equipment Corporation, 100 Northwest Point Blvd, Suite 100E, Elk Grove Village, IL 60007, USA.

We describe computer programs that predict the most energetically favorable secondary structures in growing RNA sequences, generate a sequential display of the growing structures, and monitor the predicted participation of intramolecular sites in secondary structure. These programs may provide insight into the relationships between messenger RNA secondary structure and expressibility.

Received on August 10, 1987; accepted on October 17, 1987

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