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© 1988 IRL Press Ltd

PARA-SITE: a computer algorithm for rapidly analyzing the physical-chemical properties of amino acid sequences at sites of co- and post-translational protein processing

Rodney J. Folz 1 and Jeffrey I. Gordon 1,2

1Departments of Biological Chemistry, Washington University School of Medicine Box 8094, St Louis, MO 63110, USA
2Departments of Medicine, Washington University School of Medicine Box 8094, St Louis, MO 63110, USA

A new algorithm is presented which can be used to examine the physical-chemical properties of amino acids at sites of co-or post-translational processing. This algorithm has been incorporated into a computer program known as PARA-SITE. Thirty different parameters can be studied for amino acids which occupy comparable positions in naturally occurring proteins. PARA-SITE should aid in the design and interpretation of protein engineering experiments which seek to dissect structure/ activity relationships.

Received on August 17, 1987; accepted on November 23, 1987

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