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© 1988 IRL Press Ltd

An algorithm for simultaneous comparison of several sequences

Mauno Vihinen

Department of Biochemistry, University of Turku 20500 Turku, Finland

An algorithm was developed to compare simultaneously several DNA, RNA or protein sequences. With the algorithm, conserved regions of one sequence are located by doing pairwise comparisons with other sequences, which is advantageous in planning site-directed mutagenesis studies. The observation matrices filled with scores of comparisons are superimposed and added together and those points having values greater than or equal to stringency are accepted. The predicted secondary structural features can also be compared.

Received on August 21, 1987; accepted on November 20, 1987

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