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© IRL Press Limited

A computer program to display codon changes caused by mutagenesis

Karl Sirotkin

Theoretical Division, Group T-10, Mail Stop K710, Los Alamos National Laboratory Los Alamos, NM 87545 Department of Microbiology and Graduate Program in Cellular, Molecular and Developmental Biology, University of Tennessee Knoxville, TN 37996-0845, USA

A FORTRAN program for displaying the correspondence between codon changes and different possible base changes is presented. Changes of both single bases and dimers are considered. The user can specify the mutagenesis spectrum. Additionally, the user can choose whether or not to consider single or double events in a codon and whether or not to consider the possibility that the change of two bases (a dimer) can overlap a codon boundary. Furthermore, a variety of ways may be chosen to display and summarize the codon changes that can result from the specified mutagenesis. A user-supplied sequence or the genetic code table can be analyzed.

Received on January 27, 1987; accepted on September 4, 1987

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