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© IRL Press Limited

HYLAS: program for generating H curves (abstract three-dimensional representations of long DNA sequences)

Eugene Hamori , Gabor Varga and James J. LaGuardia

Department of Biochemistry, School of Medicine, Tulane University New Orleans, LA 70112, USA

To whom reprint requests should be sent

The computer program HYLAS generates from a standard DNA letter sequence a three-dimensional space curve (H curve) which embodies the entire information content of the original nucleotide sequence. The program can display H curves either as two-dimensional (front and side view) projections or as stereo-pair images. The curves can be marked at specific nucleotide locations, annotated, rotated for observation from any viewing angle, and manipulated for convenient side-by-side comparisons. Unlike the cumbersome letter sequences, H curves can be drastically condensed in size without losing their ability to reflect the global nucleotide-distribution pattern of the entire DNA sequence. Often, biologically important loci can be visually identified on the H curves. HYLAS is written in FORTRAN with separate mainframe (IBM- VM/CMS) and microcomputer (MS-DOS) versions. It uses the Tektronix-TCS library of graphic subroutines.

Received on October 24, 1988; accepted on July 15, 1989

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