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/ Oxford University Press

On searching for the active sites in proteins and peptide hormones

Andrew E. Gabrielian *, Vadim S. Ivanov and Alexander T. Kozhich

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences Moscow 117871, V-437, Miklukho-Maklaya 16/10, USSR

*To whom reprint requests should be sent

An essential part of structure—functional studies of proteins is the search for sites responsible for specific functional activity. The information theory can be of much help in such a search. According to this theory, rarely occurring oligomers contain more information and thus are more likely to take part in forming the active site. We used frequencies of ocurrences of amino acids (mean and for each polypeptide) to search for clusters of highly informative amino acids by the moving window smoothing method. In 16 out of 19 peptide hormones such sequences were active sites known from literature.

Received on January 10, 1989; accepted on August 21, 1989

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