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/ Oxford University Press

SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry

Hermann Georg Holzhütter and Alfredo Colosimo 1,*

Institute of Biochemistry Humboldt University Berlin, GDR
1Institute of Biochemical Sciences, University ‘G.D' Annunzio’ 66100 Chieti, Italy

*To whom correspondence should be addressed

A software package suitable for personal computers and designed to handle simulation and fitting problems related to the study of biomolecules under pre-steady and steady state conditions is presented, and its overall architecture as well as the implemented algorithms illustrated. The peculiar features of the package are: (i) integrated capability of simulating dynamic models and fitting to them experimental data; (ii) handling of stiff problems; (iii) free use of algebraic as well as differential equations; (iv) objective comparison of models of different complexity. The above features are discussed through a number of examples taken from the direct experience of the authors in enzyme kinetics and ligand binding.

Received on May 23, 1989; accepted on August 21, 1989

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