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/ Oxford University Press

Statistical significance of some complex nucleotide combinations: a comparison of DNA models

G.M. Suboch * and Yu.A. Sprizhitsky

Institute of Molecular Genetics, USSR Academy of Sciences Kurchatov Square, Moscow 123182, USSR

*To whom requests for reprints should be sent

DNA is modelled as a sequence of nucleotide runs. This model is shown to provide a more adequate description of the observed frequencies of occurrence of local homopurine-homopyrimidine mirror repeats than the second-order homogeneous Markov chain model. The procedure is described for estimating the statistical significance of the occurrence of some complex nucleotide combinations in DNA.

Received on August 21, 1989; accepted on August 25, 1989

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