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© IRL Press

MetaModel: a program for modelling and control analysis of metabolic pathways on the IBM PC and compatibles

Athel Cornish-Bowden and Jan-Hendrik S. Hofmeyr 1

Centre de Biochimie et de Biologie Moléculaire, Centre National de la Recherche Scientifique 31 chemin Joseph-Aiguier, Boîte Postale 71, 13402 Marseille Cedex 9, France
1Department of Biochemistry, University of Stellenbosch Stellenbosch 7600, South Africa

MetaModel is a user-friendly program for calculating steady-state fluxes and metabolite concentrations of metabolic systems on the IBM PC and compatible computers. For any steady state that is obtained, one can then calculate a matrix of elasticity coefficients at that steady state, or a matrix of control and response coefficients. It thus offers a simple way to calculate the control structure of a pathway: it provides not only an educational tool that allows the student to verify empirically the classic summation relationships of metabolic control analysis but also a research tool for addressing ‘what if?’ questions about the behaviour of metabolic systems. Results can not only be printed or stored in a file, but can also be written to a special file that can be read by popular spreadsheet programs, thereby giving access to rapid, flexible and powerful methods for subsequent analysis and plotting of these results.

Received on August 27, 1990; accepted on October 17, 1990

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