Skip Navigation

This Article
Right arrow Full Text (Print PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Fitch, D. H.A.
Right arrow Articles by Goodman, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Fitch, D. H.A.
Right arrow Articles by Goodman, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© IRL Press

Phylogenetic scanning: a computer-assisted algorithm for mapping gene conversions and other recombinational events

David H.A. Fitch and Morris Goodman 1

Department of Molecular Genetics, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461
1Department of Anatomy, Wayne State University School of Medicine 550 East Canfield Avenue, Detroit, MI 48201, USA

An algorithm, ‘phylogenetic scanning’, is described for mapping gene conversion events where comparative DNA sequence data are available from different species. In this algorithm, sets of hypothetical phylogenetic trees are constructed that describe possible sequence relationships due to gene conversions in different species lineages; these trees are then evaluated by the principle of parsimony at intervals in the sequence alignment. When used to map gene conversion events that occurred between the pair of {gamma}-globin genes of higher primates, the algorithm gives results nearly identical to those obtained using a tedious manual approach. Suggestions are also provided for adaptation of this procedure to the analysis of other recombination events.

Received on July 3, 1990; accepted on November 8, 1990

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
S. L. Kosakovsky Pond, D. Posada, M. B. Gravenor, C. H. Woelk, and S. D. W. Frost
Automated Phylogenetic Detection of Recombination Using a Genetic Algorithm
Mol. Biol. Evol., October 1, 2006; 23(10): 1891 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
C. Wiuf, T. Christensen, and J. Hein
A Simulation Study of the Reliability of Recombination Detection Methods
Mol. Biol. Evol., October 1, 2001; 18(10): 1929 - 1939.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.