Skip Navigation

This Article
Right arrow Full Text (Print PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Letellier, T.
Right arrow Articles by Mazat, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Letellier, T.
Right arrow Articles by Mazat, J.-P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© IRL Press

CONTROL: software for the analysis of the control of metabolic networks

Thierry Letellier , Christine Reder 1 and Jean-Pierre Mazat 2

Institute de Biochimie Cellulaire et Neurochimie-CNRS and Université Bordeaux II, 146 rue Léo-Saigant, 33076 Bordeaux-Cedex
1 Mathématiques et Informatique, Université Bordeaux 1 33405 Talence-Cedex, France

2 To whom reprint requests should be sent

The program CONTROL is based on metabolic control theory and uses the method developed by Reder (1988). In this theory, two sets of parameters are defined in the vicinity of a steady-state: the elasticity coefficients which describe the local behaviour of the isolated enzymes, and the control coefficients which express the response of the whole metabolic network to perturbations at a given step. The theory shows that relationships exist between the control coefficients (summation relationships or structural relationships) and also between the two types of coefficients (control and elasticity coefficients: connectivity relationships). The program CONTROL is divided into two parts (sub-menus). The first one calculates all the control coefficients (flux and concentrations) of a metabolic network from the elasticity coefficients. Using the second menu, the symbolic relationships are obtained between the control coefficients (summation relationships) and between the control coefficients and the elasticity coefficients (connectivity relationships). These two sub-menus can be applied independently to any metabolic network (to date limited to 19 steps and 19 metabolites).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.