Skip Navigation

This Article
Right arrow Full Text (Print PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lee, J.
Right arrow Articles by Lee, H. P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lee, J.
Right arrow Articles by Lee, H. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© Oxford University Press

Covariance adjustment of survival curves based on Cox's proportional hazards regression model

James Lee , Carl Yoshizawa 1, Lynne Wilkens 2 and H. P. Lee

Department of Community, Occupational and Family Medicine, National University of Singapore Lower Kent Ridge Road, Singapore 0511
1Berlex Laboratories Inc, Alameda, CA
2Cancer Research Center of Hawaii Honolulu, HI, USA

Cox's proportional hazards regression model is a useful statistical tool for the analysis of ‘survival data’ from longitudinal studies. This multivariate method compares the ‘survival experience’ between two or more exposure groups while allowing for simultaneous adjustment of confounding due to one or more covariates. In addition to the summary regression statistics, further insight on the exposure–response relationship can be gained by visually examining the covariates–adjusted survival curves in the respective comparison groups. Covariates–adjusted survival curves are usually computed by the ‘average covariate method’. This method is, however, subject to potential drawbacks. A method that avoids these drawbacks is to estimate adjusted survival curves by the corrected group prognostic curves approach. We have written a computer program to construct survival curves by the latter method. The program is coded in the Interactive Matrix Language of SAS.

Received on March 5, 1991; accepted on August 16, 1991

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JAMAHome page
D. T. Mangano, Y. Miao, A. Vuylsteke, I. C. Tudor, R. Juneja, D. Filipescu, A. Hoeft, M. L. Fontes, Z. Hillel, E. Ott, et al.
Mortality Associated With Aprotinin During 5 Years Following Coronary Artery Bypass Graft Surgery
JAMA, February 7, 2007; 297(5): 471 - 479.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. C. Beinart, P. Kolm, E. Veledar, Z. Zhang, E. M. Mahoney, O. Bouin, S. Gabriel, J. Jackson, R. Chen, J. Caro, et al.
Long-Term Cost Effectiveness of Early and Sustained Dual Oral Antiplatelet Therapy With Clopidogrel Given for Up to One Year After Percutaneous Coronary Intervention: Results From the Clopidogrel for the Reduction of Events During Observation (CREDO) Trial
J. Am. Coll. Cardiol., September 6, 2005; 46(5): 761 - 769.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. S. Weintraub, E. M. Mahoney, A. Lamy, S. Culler, Y. Yuan, J. Caro, S. Gabriel, S. Yusuf, and CURE Study Investigators
Long-term cost-effectiveness of clopidogrel given for up to one year in patients with acute coronary syndromes without ST-segment elevation
J. Am. Coll. Cardiol., March 15, 2005; 45(6): 838 - 845.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. P. Vivekananthan, E. H. Blackstone, C. E. Pothier, and M. S. Lauer
Heart rate recovery after exercise is apredictor of mortality, independent of the angiographic severity of coronary disease
J. Am. Coll. Cardiol., September 3, 2003; 42(5): 831 - 838.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
W. A. Ghali, H. Quan, R. Brant, G. van Melle, C. M. Norris, P. D. Faris, P. D. Galbraith, M. L. Knudtson, and for the APPROACH Investigators
Comparison of 2 Methods for Calculating Adjusted Survival Curves From Proportional Hazards Models
JAMA, September 26, 2001; 286(12): 1494 - 1497.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.