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© Oxford University Press

BIOSITE: a program for the interactive comparison of aligned homologous protein sequences

V. B. Cockcroft 1,2, J. T. Pedersen 1, G. G. Lunt 2 and D. J. Osguthorpe 1

1Molecular Graphics Unit, Bath University Bath BA2 7AY, UK
2Biochemistry Department, Bath University Bath BA2 7AY, UK

A program, BIOSITE, providing for the interactive visual comparison of aligned homologous amino-acid sequences is presented, including an example of its application. The program allows for two types of comparison sequence to be generated: an ‘identity’ sequence and a ‘difference’ sequence. These may be used on subsets of sequences and in further comparisons to identify candidate sites involved in a distinct functional property. The program should prove a useful tool for biologists engaged in understanding sequence—function relationships.

Received on January 16, 1991; accepted on May 17, 1991

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