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© Oxford University Press

CLUSTAL V: improved software for multiple sequence alignment

Desmond G. Higgins , Alan J. Bleasby 1 and Rainer Fuchs

European Molecular Biology Laboratory Postfach 10.2209, 6900 Heidelberg, FRG
1Daresbury Laboratory Warrington WA4 4AD, UK

The CLUSTAL package of multiple sequence alignment programs has been completely rewritten and many new features added. The new software is a single program called CLUSTAL V, which is written in C and can be used on standard C compiler. The main new features are the ability to store and reuse old alignments and the ability to calculate phylogenetic trees after alignment. The program is simple to use, completely menu driven and on-line help is provided.


Received on August 5, 1991; accepted on August 23, 1991

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Mol Biol EvolHome page
K. Takahashi and N. Okada
Mosaic Structure and Retropositional Dynamics During Evolution of Subfamilies of Short Interspersed Elements in African Cichlids
Mol. Biol. Evol., August 1, 2002; 19(8): 1303 - 1312.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
M. J. Romanowski, R. E. Soccio, J. L. Breslow, and S. K. Burley
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain
PNAS, May 14, 2002; 99(10): 6949 - 6954.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
D. A. Mason, R. J. Fleming, and D. S. Goldfarb
Drosophila melanogaster Importin {alpha}1 and {alpha}3 Can Replace Importin {alpha}2 During Spermatogenesis but Not Oogenesis
Genetics, May 1, 2002; 161(1): 157 - 170.
[Abstract] [Full Text] [PDF]


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MycologiaHome page
Q. Shen, D. M. Geiser, and D. J. Royse
Molecular phylogenetic analysis of Grifola frondosa (maitake) reveals a species partition separating eastern North American and Asian isolates
Mycologia, May 1, 2002; 94(3): 472 - 482.
[Abstract] [Full Text] [PDF]


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J Med MicrobiolHome page
C.-M. SHIH and L.-L. CHAO
Genetic analysis of the outer surface protein C gene of Lyme disease spirochaetes (Borrelia burgdorferi sensu lato) isolated from rodents in Taiwan
J. Med. Microbiol., April 1, 2002; 51(4): 318 - 325.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
J. Zhang, K. D. Dyer, and H. F. Rosenberg
RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta
Nucleic Acids Res., March 1, 2002; 30(5): 1169 - 1175.
[Abstract] [Full Text] [PDF]


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J Exp BotHome page
X. Chen, T. Kanokporn, Q. Zeng, T. A. Wilkins, and A. J. Wood
Characterization of the V-type H(+)-ATPase in the resurrection plant Tortula ruralis: accumulation and polysomal recruitment of the proteolipid c subunit in response to salt-stress
J. Exp. Bot., February 1, 2002; 53(367): 225 - 232.
[Abstract] [Full Text] [PDF]


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Plant Physiol.Home page
M. Eicks, V. Maurino, S. Knappe, U.-I. Flugge, and K. Fischer
The Plastidic Pentose Phosphate Translocator Represents a Link between the Cytosolic and the Plastidic Pentose Phosphate Pathways in Plants
Plant Physiology, February 1, 2002; 128(2): 512 - 522.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
T. H. Oakley and C. W. Cunningham
Molecular phylogenetic evidence for the independent evolutionary origin of an arthropod compound eye
PNAS, January 24, 2002; (2002) 32483599.
[Abstract] [Full Text] [PDF]


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Antimicrob. Agents Chemother.Home page
A. Philippon, G. Arlet, and G. A. Jacoby
Plasmid-Determined AmpC-Type {beta}-Lactamases
Antimicrob. Agents Chemother., January 1, 2002; 46(1): 1 - 11.
[Full Text] [PDF]


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Nucleic Acids ResHome page
C. Lanave, F. Licciulli, M. De Robertis, A. Marolla, and M. Attimonelli
Update of AMmtDB: a database of multi-aligned Metazoa mitochondrial DNA sequences
Nucleic Acids Res., January 1, 2002; 30(1): 174 - 175.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
E. Karatan, M. M. Saulmon, M. W. Bunn, and G. W. Ordal
Phosphorylation of the Response Regulator CheV Is Required for Adaptation to Attractants during Bacillus subtilis Chemotaxis
J. Biol. Chem., November 16, 2001; 276(47): 43618 - 43626.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
G. C. T. Pipes, Q. Lin, S. E. Riley, and C. S. Goodman
The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila
Development, November 15, 2001; 128(22): 4545 - 4552.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
J. B. Bonanno, C. Edo, N. Eswar, U. Pieper, M. J. Romanowski, V. Ilyin, S. E. Gerchman, H. Kycia, F. W. Studier, A. Sali, et al.
Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis
PNAS, November 6, 2001; 98(23): 12896 - 12901.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
L. K. Bachir, J.-N. Laverriere, and R. Counis
Isolation and Characterization of a Rat Nitric Oxide Synthase Type I Gene Promoter that Confers Expression and Regulation in Pituitary Gonadotrope Cells
Endocrinology, November 1, 2001; 142(11): 4631 - 4642.
[Abstract] [Full Text] [PDF]


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Protein Eng Des SelHome page
F. Pazos and A. Valencia
Similarity of phylogenetic trees as indicator of protein-protein interaction
Protein Eng. Des. Sel., September 1, 2001; 14(9): 609 - 614.
[Abstract] [Full Text] [PDF]


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Mol Biol EvolHome page
M. N. Cortinas and E. P. Lessa
Molecular Evolution of Aldolase A Pseudogenes in Mice: Multiple Origins, Subsequent Duplications, and Heterogeneity of Evolutionary Rates
Mol. Biol. Evol., September 1, 2001; 18(9): 1643 - 1653.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
M. Battilani, A. Scagliarini, E. Tisato, C. Turilli, I. Jacoboni, R. Casadio, and S. Prosperi
Analysis of canine parvovirus sequences from wolves and dogs isolated in Italy
J. Gen. Virol., July 1, 2001; 82(7): 1555 - 1560.
[Abstract] [Full Text] [PDF]


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J. Clin. Microbiol.Home page
J. M. J. Logan, K. J. Edwards, N. A. Saunders, and J. Stanley
Rapid Identification of Campylobacter spp. by Melting Peak Analysis of Biprobes in Real-Time PCR
J. Clin. Microbiol., June 1, 2001; 39(6): 2227 - 2232.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
V. Hernando-Rico, J. F. Martin, I. Santamarta, and P. Liras
Structure of the ask-asd operon and formation of aspartokinase subunits in the cephamycin producer 'Amycolatopsis lactamdurans'
Microbiology, June 1, 2001; 147(6): 1547 - 1555.
[Abstract] [Full Text] [PDF]


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Protein Eng Des SelHome page
D. Bur, G. E. Dale, and C. Oefner
A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP)
Protein Eng. Des. Sel., May 1, 2001; 14(5): 337 - 341.
[Abstract] [Full Text] [PDF]


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Biol. Reprod.Home page
N. Fontanier-Razzaq, T. G. McEvoy, J. J. Robinson, and W. D. Rees
DNA Damaging Agents Increase gadd153 (CHOP-10) Messenger RNA Levels in Bovine Preimplantation Embryos Cultured In Vitro
Biol Reprod, May 1, 2001; 64(5): 1386 - 1391.
[Abstract] [Full Text]


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Proc. Natl. Acad. Sci. USAHome page
M. L. Durbin, A. L. Denton, and M. T. Clegg
Dynamics of mobile element activity in chalcone synthase loci in the common morning glory (Ipomoea purpurea)
PNAS, April 12, 2001; (2001) 91095498.
[Abstract] [Full Text]


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Antimicrob. Agents Chemother.Home page
A. J. Maguire, D. F. J. Brown, J. J. Gray, and U. Desselberger
Rapid Screening Technique for Class 1 Integrons in Enterobacteriaceae and Nonfermenting Gram-Negative Bacteria and Its Use in Molecular Epidemiology
Antimicrob. Agents Chemother., April 1, 2001; 45(4): 1022 - 1029.
[Abstract] [Full Text]


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GeneticsHome page
R. M. Marquez, M. A. Singer, N. T. Takaesu, W. R. Waldrip, Y. Kraytsberg, and S. J. Newfeld
Transgenic Analysis of the Smad Family of TGF-{beta} Signal Transducers in Drosophila melanogaster Suggests New Roles and New Interactions Between Family Members
Genetics, April 1, 2001; 157(4): 1639 - 1648.
[Abstract] [Full Text]


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Br J OphthalmolHome page
P. R BADENOCH, D. J COSTER, B. L WETHERALL, H. T BRETTIG, M. A ROZENBILDS, A. DRENTH, and G. WAGELS
Pythium insidiosum keratitis confirmed by DNA sequence analysis
Br J Ophthalmol, April 1, 2001; 85(4): 496g - 496.
[Full Text]


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Proc. Natl. Acad. Sci. USAHome page
M. C. Fisher, G. L. Koenig, T. J. White, G. San-Blas, R. Negroni, I. G. Alvarez, B. Wanke, and J. W. Taylor
Biogeographic range expansion into South America by Coccidioides immitis mirrors New World patterns of human migration
PNAS, March 29, 2001; (2001) 71406098.
[Abstract] [Full Text]


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J. Pharmacol. Exp. Ther.Home page
K. L. Morse, J. Behan, T. M. Laz, R. E. West Jr., S. A. Greenfeder, J. C. Anthes, S. Umland, Y. Wan, R. W. Hipkin, W. Gonsiorek, et al.
Cloning and Characterization of a Novel Human Histamine Receptor
J. Pharmacol. Exp. Ther., March 1, 2001; 296(3): 1058 - 1066.
[Abstract] [Full Text]


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IOVSHome page
Y. Liu, Y.-C. Shen, J. S. Rest, P. A. Raymond, and D. J. Zack
Isolation and Characterization of a Zebrafish Homologue of the Cone Rod Homeobox Gene
Invest. Ophthalmol. Vis. Sci., February 1, 2001; 42(2): 481 - 487.
[Abstract] [Full Text]


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J. Clin. Microbiol.Home page
D. Moissenet, P. Bidet, A. Garbarg-Chenon, G. Arlet, and H. Vu-Thien
Ralstonia paucula (Formerly CDC Group IV c-2): Unsuccessful Strain Differentiation with PCR-Based Methods, Study of the 16S-23S Spacer of the rRNA Operon, and Comparison with Other Ralstonia Species (R. eutropha, R. pickettii, R. gilardii, and R. solanacearum)
J. Clin. Microbiol., January 1, 2001; 39(1): 381 - 384.
[Abstract] [Full Text]


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J. Clin. Microbiol.Home page
Y. Sako, M. Nakao, T. Ikejima, X. Z. Piao, K. Nakaya, and A. Ito
Molecular Characterization and Diagnostic Value of Taenia solium Low-Molecular-Weight Antigen Genes
J. Clin. Microbiol., December 1, 2000; 38(12): 4439 - 4444.
[Abstract] [Full Text]


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J. Clin. Microbiol.Home page
A. Saito-Ito, M. Tsuji, Q. Wei, S. He, T. Matsui, M. Kohsaki, S. Arai, T. Kamiyama, K. Hioki, and C. Ishihara
Transfusion-Acquired, Autochthonous Human Babesiosis in Japan: Isolation of Babesia microti-Like Parasites with hu-RBC-SCID Mice
J. Clin. Microbiol., December 1, 2000; 38(12): 4511 - 4516.
[Abstract] [Full Text]


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J. Bacteriol.Home page
K. Atarashi and A. Kaji
Inhibitory Effect of Heterologous Ribosome Recycling Factor on Growth of Escherichia coli
J. Bacteriol., November 1, 2000; 182(21): 6154 - 6160.
[Abstract] [Full Text]


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MicrobiologyHome page
Y. Wang and Z. Zhang
Comparative sequence analyses reveal frequent occurrence of short segments containing an abnormally high number of non-random base variations in bacterial rRNA genes
Microbiology, November 1, 2000; 146(11): 2845 - 2854.
[Abstract] [Full Text]



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