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© Oxford University Press

Quantitative characterization of antigens using monoclonal antibody reactivities

Joaquín Dopazo , Ana Taberner 1 and Andrés Moya 2

INIA—Sanidad Animal. Embajadores 68, 28012 Madrid
1 UE1 de Fitopatología, Centro de Investigaciones Biológicas (CSIC), Velazquez 144, 28006 Madrid
2Departament de Genètica, Universitat de València. Dr Moliner 50 461(X) Valencia, Spain

A multipurpose program that empirically relates antigenic reactivities with monoclonal antibodies (MAbs) to genetic distances is presented. The program uses a set of known genetic pairwise distances to weigh each MAb depending on its capacity to define groups of taxonomically related antigens. This allows highly accurate identification and classification of unknown antigens. Also, the weights obtained constitute a quantitative measure of epitope conservation and can be used for improved vaccine design.

Received on January 10, 1992; accepted on May 21, 1992

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