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© Oxford University Press

Electrogenic property of Na +, K+ -ATPase through computer simulation

Minal P. Mujumdar and Chanchal K. Mitra 1

Centre for Atmospheric Sciences, Biomechamcs Division, Indian Institute of Technology New Delhi 110016
1School of Life Sciences, University of Hyderabad Hyderabad 500134, India

A computer simulation of the electrogenic nature of the membrane-bound Na+, K+-ATPase is presented. The model involves coupling two simulation systems for passive and active transports, using a minimum of empirical parameters, and studies the contribution of the pump to the membrane potential. The simulation results indicate that electrogenic active transport accelerates the restoration of the resting electrochemical gradients and contributes ~0.44–1.1 mV to the resting potential of the membrane, depending on the Na:K coupling ratio. The effect of membrane potential and the physical positioning of the enzyme from the passive transporting channel on the enzyme function is also presented. The validity of the model is checked by comparing our results with reported literature values.

Received on June 8, 1992; accepted on August 14, 1992

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