Skip Navigation

This Article
Right arrow Full Text (Print PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Maksyutov, A.Z.
Right arrow Articles by Zagrebelnaya, E.S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Maksyutov, A.Z.
Right arrow Articles by Zagrebelnaya, E.S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© Oxford University Press

ADEPT: a computer program for prediction of protein antigenic determinants

A.Z. Maksyutov and E.S. Zagrebelnaya

Department of Mathematical Modelling, Institute of Molecular Biology Russia, 633159, Novosibirsk region, Koltsovo

ADEPT, a program that can be used for prediction of protein antigenic determinants from the amino acid sequence alone for the cases of humoral and cellular immune response, is described. Most methods presently utilized for this purpose are implemented in the program along with some original parameters for the case of humoral immune response. There is also a possibility to combine several methods for the case of humoral immune response, which provides a means to create new predictive methods. ADEPT also includes a literature-derived database of proteins in the SWISS-PROT standard with experimentally determined antigenic determinants, so the predictive ability of new methods can be assessed within the program and corresponding statistical information is calculated. ADEPT may be useful for solving vamious tasks involving the delineation of antigenic regions on proteins or characterization of peptide fragments, arising, for examnple, in protein engineering (e.g. selection of protein portions most suitable for insertion of peptide sequences that are antigenically active or possessing other desired characteristics), and in particular for construction of vaccines containing B- and/or T-cell epitopes, as well as for other problems of medico-biological research.

Received on March 6, 1992; accepted on December 1, 1992

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BioinformaticsHome page
C. Lundegaard, O. Lund, C. Kesmir, S. Brunak, and M. Nielsen
Modeling the adaptive immune system: predictions and simulations
Bioinformatics, December 15, 2007; 23(24): 3265 - 3275.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
P. Haste Andersen, M. Nielsen, and O. Lund
Prediction of residues in discontinuous B-cell epitopes using protein 3D structures
Protein Sci., November 1, 2006; 15(11): 2558 - 2567.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.