Bioinformatics Advance Access published online on February 25, 2009
Bioinformatics, doi:10.1093/bioinformatics/btp069
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BISEN: Biochemical Simulation Environment
1 BioModeling and bioInformatics, BioMedical Engineering, Eindhoven University of Technology, The Netherlands.
2Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226. email:dbeard{at}mcw.edu
3Lilly-Singapore Centre for Drug Discovery Pte Ltd, Singapore
*To whom correspondence should be addressed. Prof. Daniel Beard, E-mail: dbeard{at}mcw.edu
| Abstract |
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Summary: The Biochemical Simulation Environment (BISEN) is a suite of tools for generating equations and associated computer programs for simulating biochemical systems in the MATLAB® computing environment. This is the first package that can generate appropriate systems of differential equations for user-specified multicompart-ment systems of enzymes and transporters accounting for detailed biochemical thermodynamics, rapid equilibria of multiple biochemical species, and dynamic proton and metal ion buffering.
Availability: The software and a user's manual (including several tutorial examples) are available at bbc.mcw.edu/BISEN.
Associate Editor: Prof. Alfonso Valencia
Received on November 24, 2008; revised on January 23, 2009; accepted on January 28, 2009