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Bioinformatics Advance Access published online on February 25, 2009

Bioinformatics, doi:10.1093/bioinformatics/btp069
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© The Author (2009). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

BISEN: Biochemical Simulation Environment

J. Vanlier 1, F. Wu 2, F. Qi 2, K.C. Vinnakota 2, Y. Han 2, R.K. Dash 2, F. Yang 3 and D.A. Beard 2,*

1 BioModeling and bioInformatics, BioMedical Engineering, Eindhoven University of Technology, The Netherlands.
2Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226. email:dbeard{at}mcw.edu
3Lilly-Singapore Centre for Drug Discovery Pte Ltd, Singapore

*To whom correspondence should be addressed. Prof. Daniel Beard, E-mail: dbeard{at}mcw.edu


   Abstract

Summary: The Biochemical Simulation Environment (BISEN) is a suite of tools for generating equations and associated computer programs for simulating biochemical systems in the MATLAB® computing environment. This is the first package that can generate appropriate systems of differential equations for user-specified multicompart-ment systems of enzymes and transporters accounting for detailed biochemical thermodynamics, rapid equilibria of multiple biochemical species, and dynamic proton and metal ion buffering.

Availability: The software and a user's manual (including several tutorial examples) are available at bbc.mcw.edu/BISEN.

Associate Editor: Prof. Alfonso Valencia


Received on November 24, 2008; revised on January 23, 2009; accepted on January 28, 2009

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