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Bioinformatics Advance Access originally published online on September 17, 2009
Bioinformatics 2009 25(23):3183-3184; doi:10.1093/bioinformatics/btp545
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© The Author 2009. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

PoreLogo: a new tool to analyse, visualize and compare channels in transmembrane proteins

Romina Oliva 1,2,*, Janet M. Thornton 2 and Marialuisa Pellegrini-Calace 2,*

1 Department of Applied Sciences, University of ‘Parthenope’ of Naples, Centro Direzionale Isola C4 80143, Naples, Italy and 2 EMBL/EBI, The Wellcome Trust Genome Campus, CB10 1SD, Hinxton, Cambridge, UK

* To whom correspondence should be addressed.


   Abstract

Summary: The increasing number of available atomic 3D structures of transmembrane channel proteins represents a valuable resource for better understanding their structure–function relationships and to eventually predict their selectivity. Herein, we present PoreLogo, an automatic tool for analysing, visualizing and comparing the amino acid composition of transmembrane channels and its conservation across the corresponding protein family.

Availability: PoreLogo is accessible as a public web server at http://www.ebi.ac.uk/thornton-srv/software/PoreLogo/.

Contacts: marial{at}ebi.ac.uk; romina.oliva{at}uniparthenope.it.

Associate Editor: Anna Tramontano


Received on June 2, 2009; revised on August 19, 2009; accepted on September 10, 2009

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