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Bioinformatics Advance Access published online on November 9, 2009
Bioinformatics, doi:10.1093/bioinformatics/btp631
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© The Author (2009). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

hPDI: a database of experimental human protein-DNA interactions

Zhi Xie 1, Shaohui Hu 2,3, Seth Blackshaw 1,3,4,5, Heng Zhu 2,3 and Jiang Qian 1,*

1 Department of Ophthalmology, 2 Department of Pharmacology & Molecular Sciences, 3 The Center for High-Throughput Biology, 4 Institute for Cell Engineering, 5 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD

*To whom correspondence should be addressed. Dr. Jiang Qian, E-mail: jiang.qian{at}jhmi.edu


  Abstract

Summary: The hPDI (human protein DNA Interactome) database holds experimental protein-DNA interaction data for humans identified by protein microarray assays. The unique characteristics of hPDI are that it contains consensus DNA-binding sequences not only for nearly 500 human TFs but also for more than 500 unconventional DNA-binding proteins, which are completely uncharacterized previously. Users can browse, search, and download a subset or the entire data via a web interface. This database is freely accessible for any academic purposes.

Availability: http://bioinfo.wilmer.jhu.edu/PDI/

Contact: jiang.qian{at}jhmi.edu

Associate Editor: Prof. Martin Bishop

Received on August 26, 2009; revised on November 3, 2009; accepted on November 3, 2009

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