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© Oxford University Press

Construction of evolutionary distance trees with TREECON for Windows: accounting for variation in nucleotide substitution rate among sites

Yves Van de Peer and Rupert De Wachter 1

Department of Biochemistry, University of Antwerp (UIA) Universiteitsplein 1, B-2610 Antwerpen, Belgium

1 To whom correspondence should be addressed

Motivation: To improve the estimation of evolutionary distances between nucieotide sequences by considering the differences in substitution rates among sites.

Results: TREECON for Windows (Van de Peer.Y. and De Wachter.R. Comput. Applic. Biosci., 9, 569–570, 1994) is a software package for the construction and drawing of phylogenetic trees based on distance data computed from nucleic acid and amino acid sequences. For nucleic acids, we here describe the implementation of a recently developed method for estimating evolutionary distances taking into account the substitution rate of individual sites in a sequence alignment.

Availability: TREECON for Windows is available on request from the authors. A small fee is asked in order to support the work and to reinvest in new computer hard- and software. More information about the program and substitution rate calibration can be found at URL http://bioc-www.uia.ac.be/u/yvdp/treeconw.html

Received on July 9, 1996; revised on November 11, 1996; accepted on December 9, 1996

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