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Bioinformatics Vol. 17 no. 1 2001
Pages 95-97
© 2001 Oxford University Press

Discovery Note

Transcription-associated protein families are primarily taxon-specific

Richard M.R. Coulson , Anton J. Enright and Christos A. Ouzounis

Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK

Received on June 14, 2000 ; revised on August 7, 2000 ; accepted on August 10, 2000

The mechanisms controlling gene regulation appear to be fundamentally different in eukaryotes and prokaryotes (Struhl (1999) Cell , 98, 1–4). To investigate this diversity further, we have analysed the distribution of all known transcription-associated proteins (TAPs), as reflected by sequence database annotations. Our results for the primary phylogenetic domains (Archaea, Bacteria and Eukaryota) show that TAP families are mostly taxon-specific and very few transcriptional regulators are common across these domains.

Contact: ouzounis{at}ebi.ac.uk


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