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Bioinformatics Vol. 17 no. 12 2001
Pages 1246-1247
© 2001 Oxford University Press


Applications Note

CONSEL: for assessing the confidence of phylogenetic tree selection

Hidetoshi Shimodaira and Masami Hasegawa

The Institute of Statistical Mathematics, 4-6-7 Minami-Azabu, Minatoku, Tokyo 106-8569, Japan

Received on May 30, 2000 ; revised on June 20, 2000 ; accepted on July 2, 2000

Summary: CONSEL is a program to assess the confidence of the tree selection by giving the p-values for the trees. The main thrust of the program is to calculate the p-value of the Approximately Unbiased (AU) test using the multi-scale bootstrap technique. This p-value is less biased than the other conventional p-values such as the Bootstrap Probability (BP), the Kishino–Hasegawa (KH) test, the Shimodaira–Hasegawa (SH) test, and the Weighted Shimodaira–Hasegawa (WSH) test. CONSEL calculates all these p-values from the output of the phylogeny program packages such as Molphy, PAML, and PAUP*. Furthermore, CONSEL is applicable to a wide class of problems where the BPs are available.

Availability: The programs are written in C language. The source code for Unix and the executable binary for DOS are found at http://www.ism.ac.jp/~shimo/

Contact: shimo{at}ism.ac.jp


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