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Bioinformatics Vol. 17 no. 2 2001
Pages 196-197
© 2001 Oxford University Press

Applications Note

MOSAIC: segmenting multiple aligned DNA sequences

Cécile André 1,*, Pierre Vincens 2,3, Jean-François Boisvieux 1 and Serge Hazout 2

1 Département de Biomathématiques, UniversitéParis 6, CHU Pitié-Salpêtrière, 91 boulevard de l’Hôpital, 75634 Paris Cedex 13, France
2 Équipe de Bioinformatique Génomique et Moléculaire, INSERM U436, UniversitéParis 7, case 7113, 2 place Jussieu, 75251 Paris Cedex 05, France
3 Département de Biologie (FR36), École Normale Supérieure, 46 rue d’Ulm, 75230 Paris Cedex 05, France

Received on June 5, 2000 ; revised on September 15, 2000 ; accepted on October 5, 2000

Summary: MOSAIC is a set of tools for the segmentation of multiple aligned DNA sequences into homogeneous zones. The segmentation is based on the distribution of mutational events along the alignment. As an example, the analysis of one repeated sequence belonging to the subtelomeric regions of the yeast genome is presented.

Availability: Free access from ftp://ftp.biomath.jussieu.fr/pub/papers/MOSAIC

Contact: can{at}biomath.jussieu.fr

* To whom correspondence should be addressed.


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