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Bioinformatics Vol. 17 no. 4 2001
Pages 381-382
© 2001 Oxford University Press

Applications Note

MutaProt: a web interface for structural analysis of point mutations

Eran Eyal *, Rafael Najmanovich , Vladimir Sobolev and Marvin Edelman

Department of Plant Sciences, Weizmann Institute of Science, Rehovot 76100, Israel

Received on September 19, 2000 ; revised on December 4, 2000 ; accepted on December 21, 2000

Summary: A web-based tool, termed ‘MutaProt’, is described which analyses pairs of PDB files whose members differ in one, or two, amino acids. MutaProt examines the micro environment surrounding the exchanged residue(s) and can be searched by specifying a PDB ID, keywords, or any pair of amino acids. Detailed information about accessibility of the exchanged residue(s) and its atomic contacts are provided based on CSU software (Sobolev et al. , Bioinformatics , 15, 327–332, 1999). An interactive 3D presentation of the superimposed regions around the mutation(s) is included. MutaProt is updated weekly.

Availability: http://www.bioinfo.weizmann.ac.il/MutaProt

Contact: eran.eyal{at}weizmann.ac.il

* To whom correspondence should be addressed.


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