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Bioinformatics Vol. 18 no. 1 2002
Pages 207-208
© 2002 Oxford University Press


Applications Note

Genesis: cluster analysis of microarray data

Alexander Sturn 1,2, John Quackenbush 2 and Zlatko Trajanoski 1,*

1 Institute of Biomedical Engineering, Graz University of Technology, Krenngasse 37, 8010 Graz, Austria
2 The Institute for Genomic Research, Rockville, MD 20850, USA

Received on June 23, 2000 ; revised on August 21, 2000 ; accepted on September 5, 2000

Summary: A versatile, platform independent and easy to use Java suite for large-scale gene expression analysis was developed. Genesis integrates various tools for microarray data analysis such as filters, normalization and visualization tools, distance measures as well as common clustering algorithms including hierarchical clustering, self-organizing maps, k-means, principal component analysis, and support vector machines. The results of the clustering are transparent across all implemented methods and enable the analysis of the outcome of different algorithms and parameters. Additionally, mapping of gene expression data onto chromosomal sequences was implemented to enhance promoter analysis and investigation of transcriptional control mechanisms.

Availability: http://genome.tugraz.at

Contact: zlatko.trajanoski{at}tugraz.at

* To whom correspondence should be addressed.


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Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood
PNAS, February 28, 2006; 103(9): 3480 - 3485.
[Abstract] [Full Text] [PDF]


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JEMHome page
M. Hammer, J. Mages, H. Dietrich, A. Servatius, N. Howells, A. C.B. Cato, and R. Lang
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
J. Exp. Med., January 23, 2006; 203(1): 15 - 20.
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Mol. Cell. Biol.Home page
D. J. Combs, R. J. Nagel, M. Ares Jr., and S. W. Stevens
Prp43p Is a DEAH-Box Spliceosome Disassembly Factor Essential for Ribosome Biogenesis
Mol. Cell. Biol., January 15, 2006; 26(2): 523 - 534.
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Mol Cancer ResHome page
J. Spence, B. M. Duggan, C. Eckhardt, M. McClelland, and D. Mercola
Messenger RNAs under Differential Translational Control in Ki-ras-Transformed Cells
Mol. Cancer Res., January 1, 2006; 4(1): 47 - 60.
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NEJMHome page
F. Pages, A. Berger, M. Camus, F. Sanchez-Cabo, A. Costes, R. Molidor, B. Mlecnik, A. Kirilovsky, M. Nilsson, D. Damotte, et al.
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
N. Engl. J. Med., December 22, 2005; 353(25): 2654 - 2666.
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BloodHome page
L. Helming, J. Bose, J. Ehrchen, S. Schiebe, T. Frahm, R. Geffers, M. Probst-Kepper, R. Balling, and A. Lengeling
1{alpha},25-dihydroxyvitamin D3 is a potent suppressor of interferon {gamma}-mediated macrophage activation
Blood, December 15, 2005; 106(13): 4351 - 4358.
[Abstract] [Full Text] [PDF]


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Ann OncolHome page
T. Dutu, S. Michiels, P. Fouret, F. Penault-Llorca, P. Validire, S. Benhamou, E. Taranchon, L. Morat, D. Grunenwald, T. Le Chevalier, et al.
Differential expression of biomarkers in lung adenocarcinoma: a comparative study between smokers and never-smokers
Ann. Onc., December 1, 2005; 16(12): 1906 - 1914.
[Abstract] [Full Text] [PDF]


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Hum Mol GenetHome page
T. Enver, S. Soneji, C. Joshi, J. Brown, F. Iborra, T. Orntoft, T. Thykjaer, E. Maltby, K. Smith, R. A. Dawud, et al.
Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells
Hum. Mol. Genet., November 1, 2005; 14(21): 3129 - 3140.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
I. M. Berquin, Y. Min, R. Wu, H. Wu, and Y. Q. Chen
Expression Signature of the Mouse Prostate
J. Biol. Chem., October 28, 2005; 280(43): 36442 - 36451.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
M. Fratelli, L. O. Goodwin, U. A. Orom, S. Lombardi, R. Tonelli, M. Mengozzi, and P. Ghezzi
Gene expression profiling reveals a signaling role of glutathione in redox regulation
PNAS, September 27, 2005; 102(39): 13998 - 14003.
[Abstract] [Full Text] [PDF]


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DiabetesHome page
L. M. Sparks, H. Xie, R. A. Koza, R. Mynatt, M. W. Hulver, G. A. Bray, and S. R. Smith
A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle
Diabetes, July 1, 2005; 54(7): 1926 - 1933.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
P. J. Wild, A. Herr, C. Wissmann, R. Stoehr, A. Rosenthal, D. Zaak, R. Simon, R. Knuechel, C. Pilarsky, and A. Hartmann
Gene Expression Profiling of Progressive Papillary Noninvasive Carcinomas of the Urinary Bladder
Clin. Cancer Res., June 15, 2005; 11(12): 4415 - 4429.
[Abstract] [Full Text] [PDF]


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JCOHome page
J. Hannemann, H. M. Oosterkamp, C. A.J. Bosch, A. Velds, L. F.A. Wessels, C. Loo, E. J. Rutgers, S. Rodenhuis, and M. J. van de Vijver
Changes in Gene Expression Associated With Response to Neoadjuvant Chemotherapy in Breast Cancer
J. Clin. Oncol., May 20, 2005; 23(15): 3331 - 3342.
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Circ. Res.Home page
A. S. Barth, S. Merk, E. Arnoldi, L. Zwermann, P. Kloos, M. Gebauer, K. Steinmeyer, M. Bleich, S. Kaab, M. Hinterseer, et al.
Reprogramming of the Human Atrial Transcriptome in Permanent Atrial Fibrillation: Expression of a Ventricular-Like Genomic Signature
Circ. Res., May 13, 2005; 96(9): 1022 - 1029.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
R. J. Wisser, Q. Sun, S. H. Hulbert, S. Kresovich, and R. J. Nelson
Identification and Characterization of Regions of the Rice Genome Associated With Broad-Spectrum, Quantitative Disease Resistance
Genetics, April 1, 2005; 169(4): 2277 - 2293.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
J. G. Frye, S. Porwollik, F. Blackmer, P. Cheng, and M. McClelland
Host Gene Expression Changes and DNA Amplification during Temperate Phage Induction
J. Bacteriol., February 15, 2005; 187(4): 1485 - 1492.
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J. Virol.Home page
H. Ludwig, J. Mages, C. Staib, M. H. Lehmann, R. Lang, and G. Sutter
Role of Viral Factor E3L in Modified Vaccinia Virus Ankara Infection of Human HeLa Cells: Regulation of the Virus Life Cycle and Identification of Differentially Expressed Host Genes
J. Virol., February 15, 2005; 79(4): 2584 - 2596.
[Abstract] [Full Text] [PDF]


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BioinformaticsHome page
N. Bolshakova, F. Azuaje, and Pád. Cunningham
An integrated tool for microarray data clustering and cluster validity assessment
Bioinformatics, February 15, 2005; 21(4): 451 - 455.
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J. Biol. Chem.Home page
M. Ohsugi, C. Cras-Meneur, Y. Zhou, E. Bernal-Mizrachi, J. D. Johnson, D. S. Luciani, K. S. Polonsky, and M. A. Permutt
Reduced Expression of the Insulin Receptor in Mouse Insulinoma (MIN6) Cells Reveals Multiple Roles of Insulin Signaling in Gene Expression, Proliferation, Insulin Content, and Secretion
J. Biol. Chem., February 11, 2005; 280(6): 4992 - 5003.
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J. Bacteriol.Home page
P. Gyaneshwar, O. Paliy, J. McAuliffe, D. L. Popham, M. I. Jordan, and S. Kustu
Sulfur and Nitrogen Limitation in Escherichia coli K-12: Specific Homeostatic Responses
J. Bacteriol., February 1, 2005; 187(3): 1074 - 1090.
[Abstract] [Full Text] [PDF]


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BloodHome page
A. M. Glas, M. J. Kersten, L. J. M. J. Delahaye, A. T. Witteveen, R. E. Kibbelaar, A. Velds, L. F. A. Wessels, P. Joosten, R. M. Kerkhoven, R. Bernards, et al.
Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment
Blood, January 1, 2005; 105(1): 301 - 307.
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Nucleic Acids ResHome page
T. May, H. Hauser, and D. Wirth
Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization
Nucleic Acids Res., October 14, 2004; 32(18): 5529 - 5538.
[Abstract] [Full Text] [PDF]


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Plant CellHome page
S. Kubis, R. Patel, J. Combe, J. Bedard, S. Kovacheva, K. Lilley, A. Biehl, D. Leister, G. Rios, C. Koncz, et al.
Functional Specialization amongst the Arabidopsis Toc159 Family of Chloroplast Protein Import Receptors
PLANT CELL, August 1, 2004; 16(8): 2059 - 2077.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
K. Palyada, D. Threadgill, and A. Stintzi
Iron Acquisition and Regulation in Campylobacter jejuni
J. Bacteriol., July 15, 2004; 186(14): 4714 - 4729.
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Cancer Res.Home page
K. Almstrup, C. E. Hoei-Hansen, U. Wirkner, J. Blake, C. Schwager, W. Ansorge, J. E. Nielsen, N. E. Skakkebaek, E. R.-D. Meyts, and H. Leffers
Embryonic Stem Cell-Like Features of Testicular Carcinoma in Situ Revealed by Genome-Wide Gene Expression Profiling
Cancer Res., July 15, 2004; 64(14): 4736 - 4743.
[Abstract] [Full Text] [PDF]


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DiabetesHome page
M. Ohsugi, C. Cras-Meneur, Y. Zhou, W. Warren, E. Bernal-Mizrachi, and M. A. Permutt
Glucose and Insulin Treatment of Insulinoma Cells Results in Transcriptional Regulation of a Common Set of Genes
Diabetes, June 1, 2004; 53(6): 1496 - 1508.
[Abstract] [Full Text] [PDF]


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Clin. Cancer Res.Home page
Z. Kote-Jarai, R. D. Williams, N. Cattini, M. Copeland, I. Giddings, R. Wooster, R. H. tePoele, P. Workman, B. Gusterson, J. Peacock, et al.
Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of BRCA1 Mutation Carrier Status
Clin. Cancer Res., February 1, 2004; 10(3): 958 - 963.
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Mol. Cell. Biol.Home page
L. Bruno, R. Hoffmann, F. McBlane, J. Brown, R. Gupta, C. Joshi, S. Pearson, T. Seidl, C. Heyworth, and T. Enver
Molecular Signatures of Self-Renewal, Differentiation, and Lineage Choice in Multipotential Hemopoietic Progenitor Cells In Vitro
Mol. Cell. Biol., January 15, 2004; 24(2): 741 - 756.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
B. Weigelt, A. M. Glas, L. F. A. Wessels, A. T. Witteveen, J. L. Peterse, and L. J. van't Veer
Gene expression profiles of primary breast tumors maintained in distant metastases
PNAS, December 23, 2003; 100(26): 15901 - 15905.
[Abstract] [Full Text] [PDF]


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DiabetesHome page
B. Kutlu, A. K. Cardozo, M. I. Darville, M. Kruhoffer, N. Magnusson, T. Orntoft, and D. L. Eizirik
Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
Diabetes, November 1, 2003; 52(11): 2701 - 2719.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
D. Xu, V. Olman, L. Wang, and Y. Xu
EXCAVATOR: a computer program for efficiently mining gene expression data
Nucleic Acids Res., October 1, 2003; 31(19): 5582 - 5589.
[Abstract] [Full Text] [PDF]



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