Bioinformatics Vol. 18 no. 1 2002
Pages 207-208
© 2002 Oxford University Press
Applications Note |
Genesis: cluster analysis of microarray data
1 Institute of Biomedical Engineering, Graz
University of Technology, Krenngasse 37, 8010 Graz, Austria
2 The Institute for Genomic Research,
Rockville, MD 20850, USA
Received on June 23, 2000
; revised on August 21, 2000
; accepted on September 5, 2000
Summary: A versatile, platform independent and easy to use Java suite for large-scale gene expression analysis was developed. Genesis integrates various tools for microarray data analysis such as filters, normalization and visualization tools, distance measures as well as common clustering algorithms including hierarchical clustering, self-organizing maps, k-means, principal component analysis, and support vector machines. The results of the clustering are transparent across all implemented methods and enable the analysis of the outcome of different algorithms and parameters. Additionally, mapping of gene expression data onto chromosomal sequences was implemented to enhance promoter analysis and investigation of transcriptional control mechanisms.
Availability: http://genome.tugraz.at
Contact: zlatko.trajanoski{at}tugraz.at
* To whom correspondence should be addressed.
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P. J. Wild, A. Herr, C. Wissmann, R. Stoehr, A. Rosenthal, D. Zaak, R. Simon, R. Knuechel, C. Pilarsky, and A. Hartmann Gene Expression Profiling of Progressive Papillary Noninvasive Carcinomas of the Urinary Bladder Clin. Cancer Res., June 15, 2005; 11(12): 4415 - 4429. [Abstract] [Full Text] [PDF] |
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J. Hannemann, H. M. Oosterkamp, C. A.J. Bosch, A. Velds, L. F.A. Wessels, C. Loo, E. J. Rutgers, S. Rodenhuis, and M. J. van de Vijver Changes in Gene Expression Associated With Response to Neoadjuvant Chemotherapy in Breast Cancer J. Clin. Oncol., May 20, 2005; 23(15): 3331 - 3342. [Abstract] [Full Text] [PDF] |
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A. S. Barth, S. Merk, E. Arnoldi, L. Zwermann, P. Kloos, M. Gebauer, K. Steinmeyer, M. Bleich, S. Kaab, M. Hinterseer, et al. Reprogramming of the Human Atrial Transcriptome in Permanent Atrial Fibrillation: Expression of a Ventricular-Like Genomic Signature Circ. Res., May 13, 2005; 96(9): 1022 - 1029. [Abstract] [Full Text] [PDF] |
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R. J. Wisser, Q. Sun, S. H. Hulbert, S. Kresovich, and R. J. Nelson Identification and Characterization of Regions of the Rice Genome Associated With Broad-Spectrum, Quantitative Disease Resistance Genetics, April 1, 2005; 169(4): 2277 - 2293. [Abstract] [Full Text] [PDF] |
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J. G. Frye, S. Porwollik, F. Blackmer, P. Cheng, and M. McClelland Host Gene Expression Changes and DNA Amplification during Temperate Phage Induction J. Bacteriol., February 15, 2005; 187(4): 1485 - 1492. [Abstract] [Full Text] [PDF] |
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H. Ludwig, J. Mages, C. Staib, M. H. Lehmann, R. Lang, and G. Sutter Role of Viral Factor E3L in Modified Vaccinia Virus Ankara Infection of Human HeLa Cells: Regulation of the Virus Life Cycle and Identification of Differentially Expressed Host Genes J. Virol., February 15, 2005; 79(4): 2584 - 2596. [Abstract] [Full Text] [PDF] |
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N. Bolshakova, F. Azuaje, and Pád. Cunningham An integrated tool for microarray data clustering and cluster validity assessment Bioinformatics, February 15, 2005; 21(4): 451 - 455. [Abstract] [Full Text] [PDF] |
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M. Ohsugi, C. Cras-Meneur, Y. Zhou, E. Bernal-Mizrachi, J. D. Johnson, D. S. Luciani, K. S. Polonsky, and M. A. Permutt Reduced Expression of the Insulin Receptor in Mouse Insulinoma (MIN6) Cells Reveals Multiple Roles of Insulin Signaling in Gene Expression, Proliferation, Insulin Content, and Secretion J. Biol. Chem., February 11, 2005; 280(6): 4992 - 5003. [Abstract] [Full Text] [PDF] |
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P. Gyaneshwar, O. Paliy, J. McAuliffe, D. L. Popham, M. I. Jordan, and S. Kustu Sulfur and Nitrogen Limitation in Escherichia coli K-12: Specific Homeostatic Responses J. Bacteriol., February 1, 2005; 187(3): 1074 - 1090. [Abstract] [Full Text] [PDF] |
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A. M. Glas, M. J. Kersten, L. J. M. J. Delahaye, A. T. Witteveen, R. E. Kibbelaar, A. Velds, L. F. A. Wessels, P. Joosten, R. M. Kerkhoven, R. Bernards, et al. Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment Blood, January 1, 2005; 105(1): 301 - 307. [Abstract] [Full Text] [PDF] |
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T. May, H. Hauser, and D. Wirth Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization Nucleic Acids Res., October 14, 2004; 32(18): 5529 - 5538. [Abstract] [Full Text] [PDF] |
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S. Kubis, R. Patel, J. Combe, J. Bedard, S. Kovacheva, K. Lilley, A. Biehl, D. Leister, G. Rios, C. Koncz, et al. Functional Specialization amongst the Arabidopsis Toc159 Family of Chloroplast Protein Import Receptors PLANT CELL, August 1, 2004; 16(8): 2059 - 2077. [Abstract] [Full Text] [PDF] |
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K. Palyada, D. Threadgill, and A. Stintzi Iron Acquisition and Regulation in Campylobacter jejuni J. Bacteriol., July 15, 2004; 186(14): 4714 - 4729. [Abstract] [Full Text] [PDF] |
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K. Almstrup, C. E. Hoei-Hansen, U. Wirkner, J. Blake, C. Schwager, W. Ansorge, J. E. Nielsen, N. E. Skakkebaek, E. R.-D. Meyts, and H. Leffers Embryonic Stem Cell-Like Features of Testicular Carcinoma in Situ Revealed by Genome-Wide Gene Expression Profiling Cancer Res., July 15, 2004; 64(14): 4736 - 4743. [Abstract] [Full Text] [PDF] |
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M. Ohsugi, C. Cras-Meneur, Y. Zhou, W. Warren, E. Bernal-Mizrachi, and M. A. Permutt Glucose and Insulin Treatment of Insulinoma Cells Results in Transcriptional Regulation of a Common Set of Genes Diabetes, June 1, 2004; 53(6): 1496 - 1508. [Abstract] [Full Text] [PDF] |
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Z. Kote-Jarai, R. D. Williams, N. Cattini, M. Copeland, I. Giddings, R. Wooster, R. H. tePoele, P. Workman, B. Gusterson, J. Peacock, et al. Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of BRCA1 Mutation Carrier Status Clin. Cancer Res., February 1, 2004; 10(3): 958 - 963. [Abstract] [Full Text] [PDF] |
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L. Bruno, R. Hoffmann, F. McBlane, J. Brown, R. Gupta, C. Joshi, S. Pearson, T. Seidl, C. Heyworth, and T. Enver Molecular Signatures of Self-Renewal, Differentiation, and Lineage Choice in Multipotential Hemopoietic Progenitor Cells In Vitro Mol. Cell. Biol., January 15, 2004; 24(2): 741 - 756. [Abstract] [Full Text] [PDF] |
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B. Weigelt, A. M. Glas, L. F. A. Wessels, A. T. Witteveen, J. L. Peterse, and L. J. van't Veer Gene expression profiles of primary breast tumors maintained in distant metastases PNAS, December 23, 2003; 100(26): 15901 - 15905. [Abstract] [Full Text] [PDF] |
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B. Kutlu, A. K. Cardozo, M. I. Darville, M. Kruhoffer, N. Magnusson, T. Orntoft, and D. L. Eizirik Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells Diabetes, November 1, 2003; 52(11): 2701 - 2719. [Abstract] [Full Text] [PDF] |
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D. Xu, V. Olman, L. Wang, and Y. Xu EXCAVATOR: a computer program for efficiently mining gene expression data Nucleic Acids Res., October 1, 2003; 31(19): 5582 - 5589. [Abstract] [Full Text] [PDF] |
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