Bioinformatics Vol. 18 no. 2 2002
Pages 337-338
© 2002 Oxford University Press
Applications Note |
Generating samples under a Wright–Fisher neutral model of genetic variation
Department of Ecology and Evolution, University of Chicago, 1101 E. 57th Street, Chicago, IL 60637, USA
Received on August 8, 2001
; revised on September 13, 2001
; accepted on September 13, 2001
Summary: A Monte Carlo computer program is available to generate samples drawn from a population evolving according to a Wright–Fisher neutral model. The program assumes an infinite-sites model of mutation, and allows recombination, gene conversion, symmetric migration among subpopulations, and a variety of demographic histories. The samples produced can be used to investigate the sampling properties of any sample statistic under these neutral models.
Availability: The source code for the program (in the language C) is available at http://home.uchicago.edu/~rhudson1/source/mksamples.html.
Contact: rr-hudson{at}uchicago.edu
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U. Arunyawat, W. Stephan, and T. Stadler Using Multilocus Sequence Data to Assess Population Structure, Natural Selection, and Linkage Disequilibrium in Wild Tomatoes Mol. Biol. Evol., October 1, 2007; 24(10): 2310 - 2322. [Abstract] [Full Text] [PDF]
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H. Chen, R. E. Green, S. Paabo, and M. Slatkin The Joint Allele-Frequency Spectrum in Closely Related Species Genetics, September 1, 2007; 177(1): 387 - 398. [Abstract] [Full Text] [PDF]
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J. D. Jensen, K. R. Thornton, C. D. Bustamante, and C. F. Aquadro On the Utility of Linkage Disequilibrium as a Statistic for Identifying Targets of Positive Selection in Nonequilibrium Populations Genetics, August 1, 2007; 176(4): 2371 - 2379. [Abstract] [Full Text] [PDF]
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R. D. Hernandez, S. H. Williamson, and C. D. Bustamante Context Dependence, Ancestral Misidentification, and Spurious Signatures of Natural Selection Mol. Biol. Evol., August 1, 2007; 24(8): 1792 - 1800. [Abstract] [Full Text] [PDF]
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K. Zeng, S. Shi, and C.-I Wu Compound Tests for the Detection of Hitchhiking Under Positive Selection Mol. Biol. Evol., August 1, 2007; 24(8): 1898 - 1908. [Abstract] [Full Text] [PDF]
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