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Bioinformatics Vol. 19 no. 15 2003
Pages 2000-2001
© 2003 Oxford University Press

Applications Note

Analysing gene expressions with GRANK

W.P.H. de Boer 1,*, J.J. Oudejans 2, C.J.L.M. Meijer 2 and J. Lankelma 1

1 Department of Medical Oncology, 2 Department of Clinical Pathology, VU Medical Center, PO Box 7057, 1081 Hv Amsterdam, The Netherlands

Received on September 23, 2002 ; revised on January 27, 2003 ; accepted on May 6, 2003

Summary: Unravelling overlapping clusters of functionally linked genes is a major challenge to current clustering programs. Algorithm GRANK permits systematic study of overlap between clusters of genes of a similar expression profile and large variation across a series of microarrays.

Availability: GRANK is freely available from http://www.bio.vu.nl/microb/research/tumor.html provided one adheres to the end-user license agreement in the associated manual.

Supplementary information: Above website also supplies the in- and output files used in the example run.

Contact: All queries should be addressed to wph.deboer{at}vumc.nl

* To whom correspondence should be addressed.


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