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Bioinformatics Vol. 19 no. 2 2003
Pages 309-310
© 2003 Oxford University Press

Applications Note

MPID: MHC-Peptide Interaction Database for sequence-structure-function information on peptides binding to MHC molecules

Kunde Ramamoorthy Govindarajan 1, Pandjassarame Kangueane 3, Tin Wee Tan 1 and Shoba Ranganathan 1,2,*

1 Department of Biochemistry
2 Department of Biological Sciences, National University of Singapore, Singapore 119260
3 Bioinformatics Group, MPE, NCSV, Nanyang Technological University, Singapore 639798

Received on April 16, 2002 ; revised on July 19, 2002 ; accepted on September 2, 2002

Summary: Binding of short antigenic peptides to Major histocompatibility complex (MHC) proteins is the first step in T-cell mediated immune response. To understand the structural principles governing MHC-specific peptide recognition and binding, we have developed the MHC-Peptide Interaction Database (MPID), containing sequence-structure-function information. MPID (version 1.2) contains curated x-ray crystallographic data on 86 MHC peptide complexes, with precomputed interaction parameters (solvent accessibility, hydrogen bonds, gap volume and gap index). A user-friendly web interface and query tools will facilitate the development of predictive algorithms for MHC-peptide binding from a structural viewpoint.

Availability: Freely accessible from http://surya.bic.nus.edu.sg/mpid.

Contact: shoba{at}bic.nus.edu.sg

* To whom correspondence should be addressed.


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