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Bioinformatics Vol. 19 no. 3 2003
Pages 362-367
© 2003 Oxford University Press

LTR_STRUC: a novel search and identification program for LTR retrotransposons

Eugene M. McCarthy * and John F. McDonald

Department of Genetics, University of Georgia, Athens, GA 30602, USA

Received on February 3, 2002 ; revised on May 20, 2002 and July 11, 2002 ; accepted on August 2, 2002

Motivation: Long terminal repeat (LTR) retrotransposons constitute a substantial fraction of most eukaryotic genomes and are believed to have a significant impact on genome structure and function. Conventional methods used to search for LTR retrotransposons in genome databases are labor intensive. We present an efficient, reliable and automated method to identify and analyze members of this important class of transposable elements.

Results: We have developed a new data-mining program, LTR_STRUC (LTR retrotransposon structure program) which identifies and automatically analyzes LTR retrotransposons in genome databases by searching for structural features characteristic of such elements. LTR_STRUC has significant advantages over conventional search methods in the case of LTR retrotransposon families having low sequence homology to known queries or families with atypical structure (e.g. non-autonomous elements lacking canonical retroviral ORFs) and is thus a discovery tool that complements established methods. LTR_STRUC finds LTR retrotransposons using an algorithm that encompasses a number of tasks that would otherwise have to be initiated individually by the user. For each LTR retrotransposon found, LTR_STRUC automatically generates an analysis of a variety of structural features of biological interest.

Availability: The LTR_STRUC program is currently available as a console application free of charge to academic users from the authors.

Contact: gm{at}uga.edu mcgene{at}uga.edu

* To whom correspondence should be addressed.


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