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Bioinformatics Vol. 19 Suppl. 1 2003
Pages i118-i121
© 2003 Oxford University Press

Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes

Richard E. Green 1,2, Benjamin P. Lewis 1,3, R. Tyler Hillman 1, Marco Blanchette 2, Liana F. Lareau 2, Aaron T. Garnett 2, Donald C. Rio 2 and Steven E. Brenner 2,3,*

1 Departments of Plant and Microbial Biology
2 Molecular and Cell Biology
3 Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA

Received on January 6, 2003 ; accepted on February 20, 2003

We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003; Proc. Natl Acad. Sci. USA, 100, 189–192). Rather than being translated to yield protein, these transcripts are expected to be degraded and may be subject to regulated unproductive splicing and translation (RUST). Our initial experimental studies are consistent with these predictions and suggest an unappreciated role for NMD in several human diseases.

Contact: brenner{at}compbio.berkeley.edu

* To whom correspondence should be addressed.


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