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Bioinformatics Advance Access originally published online on April 8, 2004
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Bioinformatics 20(12) © Oxford University Press 2004; all rights reserved.

Applications Note

ArrayNorm: comprehensive normalization and analysis of microarray data

R. Pieler 1, F. Sanchez-Cabo 1,2, H. Hackl 1, G. G. Thallinger 1 and Z. Trajanoski 1,*

1 Institute of Genomics and Bioinformatics and Christian Doppler Laboratory for Genomics and Bioinformatics, Graz University of Technology, 8010 Graz, Austria and 2 Department of Biomolecular Sciences, UMIST, Manchester M60 1QD, UK

Received on July 14, 2003; accepted on February 5, 2004
Advance Access Publication April 8, 2004

Summary: ArrayNorm is a user-friendly, versatile and platform-independent Java application for the visualization, normalization and analysis of two-color microarray data. A variety of normalization options were implemented to remove the systematic and random errors in the data, taking into account the experimental design and the particularities of every slide. In addition, ArrayNorm provides a module for statistical identification of genes with significant changes in expression.

Availability: The package is freely available for academic and non-profit institutions from http://genome.tugraz.at

Contact: zlatko.trajanoski{at}tugraz.at

* To whom correspondence should be addressed.


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