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Bioinformatics Advance Access originally published online on March 25, 2004
Bioinformatics 2004 20(17):3236-3237; doi:10.1093/bioinformatics/bth191
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Bioinformatics vol. 20 issue 17 © Oxford University Press 2004; all rights reserved.

Applications Note

UniProt archive

Rasko Leinonen , Federico Garcia Diez , David Binns , Wolfgang Fleischmann , Rodrigo Lopez and Rolf Apweiler *

EMBL Outstation, The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

Received on September 17, 2003; revised on January 28, 2004; accepted on February 19, 2004
Advance Access Publication March 25, 2004

Summary: UniProt Archive (UniParc) is the most comprehensive, non-redundant protein sequence database available. Its protein sequences are retrieved from predominant, publicly accessible resources. All new and updated protein sequences are collected and loaded daily into UniParc for full coverage. To avoid redundancy, each unique sequence is stored only once with a stable protein identifier, which can be used later in UniParc to identify the same protein in all source databases. When proteins are loaded into the database, database cross-references are created to link them to the origins of the sequences. As a result, performing a sequence search against UniParc is equivalent to performing the same search against all databases cross-referenced by UniParc. UniParc contains only protein sequences and database cross-references; all other information must be retrieved from the source databases.

Availability: http://www.ebi.ac.uk/uniparc/

Contact: rolf.apweiler{at}ebi.ac.uk

* To whom correspondence should be addressed.


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