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Bioinformatics Advance Access originally published online on February 5, 2004
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Bioinformatics 20(5) © Oxford University Press 2004; all rights reserved.

Applications Note

Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity

Jakob C. Mueller * and Christophe Andreoli

Institute of Human Genetics, GSF, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

Received on August 21, 2003 ; accepted on October 14, 2003
Advance Access Publication February 5, 2004

Summary: Association studies may request more details of a specific haplotype. Haplotype-specific decay of linkage disequilibrium is such a crucial and versatile characteristic. It may be used, e.g. to search for signals of natural selection in a risk haplotype. Here, we present a web-based tool to explore the relationship between population frequency and extended linkage disequilibrium measured as haplotype homozygosity of observed haplotypes within a specified candidate region.

Availability: The web-tool is available at http://ihg.gsf.de/cgi-bin/mueller/webehh.pl

Contact: jakob.mueller{at}gsf.de

* To whom correspondence should be addressed.


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