Bioinformatics Advance Access originally published online on February 19, 2004
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Bioinformatics 20(9) © Oxford University Press 2004; all rights reserved.
Applications Note |
TANDEM: matching proteins with tandem mass spectra
1 Manitoba Centre for Proteomics, University of Manitoba, Winnipeg, MB, Canada R3T 2N2 and 2 Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA
Received on September 26, 2003; accepted on December 2, 2003
Advance Access Publication February 19, 2004
Summary: Tandem mass spectra obtained from fragmenting peptide ions contain some peptide sequence specific information, but often there is not enough information to sequence the original peptide completely. Several proprietary software applications have been developed to attempt to match the spectra with a list of protein sequences that may contain the sequence of the peptide. The application TANDEM was written to provide the proteomics research community with a set of components that can be used to test new methods and algorithms for performing this type of sequence-to-data matching.
Availability: The source code and binaries for this software are available at http://www.proteome.ca/opensource.html, for Windows, Linux and Macintosh OSX. The source code is made available under the Artistic License, from the authors.
Contact: rbeavis{at}proteome.ca
* To whom correspondence should be addressed.
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