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Bioinformatics Advance Access originally published online on March 3, 2005
Bioinformatics 2005 21(10):2539-2540; doi:10.1093/bioinformatics/bti360
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

CoC: a database of universally conserved residues in protein folds

Jason E. Donald 1, Isaac A. Hubner 1, Veronica M. Rotemberg 1, Eugene I. Shakhnovich 1 and Leonid A. Mirny 2,*

1Department of Chemistry and Chemical Biology, Harvard University 12 Oxford Street, Cambridge, MA 02138, USA
2Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology 77 Massachusetts Avenue, 16–343, Cambridge, MA 02139, USA

*To whom correspondence should be addressed.

Summary: The conservatism of conservatism (CoC) database presents statistically analyzed information about the conservation of residue positions in folds across protein families.

Availability: On the web at http://kulibin.mit.edu/coc/

Contact: leonid{at}mit.edu

Supplementary information: The website details the method and contains an FAQ and documentation, http://kulibin.mit.edu/coc/


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