Bioinformatics Advance Access originally published online on March 17, 2005
Bioinformatics 2005 21(11):2722-2729; doi:10.1093/bioinformatics/bti392
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noise-induced cooperative behavior in a multicell system
1Department of Electrical Engineering and Electronics, Osaka Sangyo University Daito, Osaka 574-8530, Japan
2Department of Mathematical Sciences, Tsinghua University Beijing 100084, China
3Institute of Industrial Science, The University of Tokyo Komaba 4-6-1, Meguro, Tokyo 153-8505, Japan
4ERATO Aihara Complexity Modelling Project, JST Oyama 45-18, Shibuya-ku, Tokyo 151-0065, Japan
*To whom correspondence should be addressed.
Motivation: All cell components exhibit intracellular noise on account of random births and deaths of individual molecules, and extracellular noise because of environment perturbations. Gene regulation in particular, is an inherently noisy process with transcriptional control, alternative splicing, translation, diffusion and chemical modification reactions, all of which involve stochastic fluctuations. Such stochastic noises may not only affect the dynamics of the entire system but may also be exploited by living organisms to actively facilitate certain functions, such as cooperative behavior and communication.
Results: We have provided a general model and an analytic tool to examine the cooperative behavior of a multicell system with both intracellular and extracellular stochastic fluctuations. A multicell system with a synthetic gene network is adopted to demonstrate the effects of noises and coupling on collective dynamics. These results establish not only a theoretical foundation but also a quantitative basis for understanding essential roles of noises on cooperative dynamics, such as synchronization and communication among cells.
Availability:
Contact: chen{at}elec.osaka-sandai.ac.jp
Supplementary information: http://www.sat.t.u-tokyo.ac.jp/research.html or http://www.elec.osaka-sandai.ac.jp/lab/chen/support.html
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Z. Li, S. Zhang, Y. Wang, X.-S. Zhang, and L. Chen Alignment of molecular networks by integer quadratic programming Bioinformatics, July 1, 2007; 23(13): 1631 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wang, L. Chen, and K. Aihara Synchronizing a multicellular system by external input: an artificial control strategy Bioinformatics, July 15, 2006; 22(14): 1775 - 1781. [Abstract] [Full Text] [PDF]
|
|