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Bioinformatics Advance Access originally published online on May 6, 2005
Bioinformatics 2005 21(14):3176-3178; doi:10.1093/bioinformatics/bti486
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Published by Oxford University Press 2005

PMUT: a web-based tool for the annotation of pathological mutations on proteins

Carles Ferrer-Costa 1, Josep Lluis Gelpí 1,2,*, Leire Zamakola 1,3, Ivan Parraga 1,3, Xavier de la Cruz 1,4 and Modesto Orozco 1,2,3,*

1Molecular Modeling and Bioinformatics Unit, Institut de Recerca Biomédica, Parc Científic de Barcelona Josep Samitier 1-5, Barcelona 08028, Spain
2Departament de Bioquímica i Biología Molecular, Facultat de Química, Universitat de Barcelona Martí i Franquès 1, Barcelona 08028, Spain
3Instituto Nacional de Bioinformàtica, Parc Científic de Barcelona Josep Samitier 1-5, Barcelona 08028, Spain
4Institució Catalana per laRecerca i Estudis Avançats (ICREA) Passeig Lluís Companys 23, 08018 Barcelona, Spain

*To whom correspondence should be addressed.

Summary: PMUT allows the fast and accurate prediction (~80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations. A graphical interface for Protein Data Bank (PDB) structures, when available, and a database containing hot spot profiles for all non-redundant PDB structures are also accessible from the PMUT server.

Availability: PMUT is freely accessible at http://mmb2.pcb.ub.es:8080/PMut/

Contact: modesto{at}mmb.pcb.ub.es

Supplementary information: http://mmb2.pcb.ub.es:8080/PMutWeb/methodology.html

Received on March 8, 2005; revised on April 13, 2005; accepted on May 3, 2005

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