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Bioinformatics Advance Access originally published online on May 6, 2005
Bioinformatics 2005 21(14):3183-3184; doi:10.1093/bioinformatics/bti480
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

SDMinP: a program to control the family wise error rate using step-down minP adjusted P-values

M. Obreiter 1, C. Fischer 2, J. Chang-Claude 1 and L. Beckmann 1,*

1German Cancer Research Center DKFZ, Department of Clinical Epidemiology Im Neuenheimer Feld 280,69120 Heidelberg, Germany
2Institute of Human Genetics, University of Heidelberg Germany

*To whom correspondence should be addressed.

Summary: SDMinP is an easy-to-use program for fast calculation of empirical and adjusted P-values for correlated and uncorrelated hypotheses in multiple testing experiments. It is based on the Free Step-Down Resampling Method for controlling the family wise error rate, and implements a variation of an efficient algorithm, which reduces the originally required re-sampling effort considerably and makes the method computationally feasible. The program is independent of the underlying test statistic and works with provided observed and permutation test statistics.

Availability: http://www.dkfz.de/SDMinP/software.html

Contact: L.beckmann{at}dkfz.de

Received on March 16, 2005; revised on April 20, 2005; accepted on April 28, 2005

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