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Bioinformatics Advance Access originally published online on May 27, 2005
Bioinformatics 2005 21(15):3318-3319; doi:10.1093/bioinformatics/bti520
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

COREX/BEST server: a web browser-based program that calculates regional stability variations within protein structures

Jason Vertrees , Phillip Barritt , Steve Whitten and Vincent J. Hilser *

Department of Human Biological Chemistry & Genetics, Sealy Center for Structural Biology, University of Texas Medical Branch at Galveston TX 77555, USA

*To whom correspondence should be addressed.

Summary: Utilizing the user-supplied coordinates of a protein structure, the COREX/BEST Server generates a structural thermodynamic ensemble. This conformational ensemble can then be used to calculate the regional variations in stability of a protein structure, and the stabilities are presented in units of energy (kcal/mol). The regional stabilities, which are calculated at the resolution of individual residues, can be mapped onto the protein structure for visual representation and downloaded from the site in the form of tab delimited text. The site provides an easy to follow summary of the theoretical and algorithmic approaches and provides links to references for more detailed descriptions.

Availability: The COREX/BEST Server may be accessed through a typical web browser by visiting http://best.utmb.edu/BEST/

Contact: vjhilser{at}utmb.edu

Received on January 18, 2005; revised on May 10, 2005; accepted on May 25, 2005

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