Bioinformatics Advance Access originally published online on June 14, 2005
Bioinformatics 2005 21(16):3435-3438; doi:10.1093/bioinformatics/bti537
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FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded
1Biological Services, Weizmann Institute of Science Rehovot 76100, Israel
2Department of Structural Biology, Weizmann Institute of Science Rehovot 76100, Israel
3Department of Neurobiology, Weizmann Institute of Science Rehovot 76100, Israel
4Department of Molecular Genetics, Weizmann Institute of Science Rehovot 76100, Israel
5Department of Biochemistry, Instituto di Ricerche di Biologia Molecolare ‘P. Angeletti’ S.p.A. I-00040 Pomezia (Rome), Italy
6Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois CH-1011 Lausanne, Switzerland
*To whom correspondence should be addressed.
Summary: An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex© has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.
Availability: FoldIndex© can be accessed at http://bioportal.weizmann.ac.il/fldbin/findex
Contact: Joel.Sussman{at}weizmann.ac.il
Supplementary information: http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/suppl/Prilusky_2005
Received on August 27, 2004; revised on May 10, 2005; accepted on June 8, 2005
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