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Bioinformatics Advance Access originally published online on July 28, 2005
Bioinformatics 2005 21(18):3697-3699; doi:10.1093/bioinformatics/bti600
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© The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions{at}oupjournals.org

SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization

Min He 1, John K. Tomfohr 1, Blythe H. Devlin 2, Marcella Sarzotti 3, M. Louise Markert 2,3 and Thomas B. Kepler 1,3,*

1Department of Biostatistics and Bioinformatics, Duke University Medical Center Durham, NC 27708, USA
2Department of Pediatrics, Duke University Medical Center Durham, NC 27708, USA
3Department of Immunology, Duke University Medical Center Durham, NC 27708, USA

*To whom correspondence should be addressed.

Summary: SpA is a web-accessible system for the management, visualization and statistical analysis of T-cell receptor spectratype data. Users upload data from their spectratype analyzers to SpA, which saves the raw data and user-defined supplementary covariates to a secure database. The statistical engine performs several data analyses and statistical summaries. The visualization engine displays spectratype histograms in a Java applet and in an image file suitable for download. All of these results are also saved to the database and remain accessible to the user. Additional statistical tools specific to the analysis of multiple spectratypes are also available through the SpA interface.

Availability: The service is freely accessible via the web at http://www.duke.edu/~kepler/spa.html. Additional technical support and specialized statistical analysis and consultation are available by arrangement with the authors and, depending on the service requested, may be subject to fee.

Contact: kepler{at}duke.edu

Received on April 29, 2005; revised on July 10, 2005; accepted on July 26, 2005

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