Bioinformatics Advance Access originally published online on October 25, 2005
Bioinformatics 2005 21(24):4427-4429; doi:10.1093/bioinformatics/bti729
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ISER: selection of differentially expressed genes from DNA array data by non-linear data transformations and local fitting
1Laboratório de Genoma FuncionalCentro de Biologia Molecular e Engenharia Genética, Universidade Estadual de Campinas Campinas 13083-875, PO Box 6010, Brazil
2Departmento de Estatística, Instituto de Matemática, Estatística e Computação Científica, Universidade Estadual de Campinas Campinas 13083-859, Brazil
3Departmento de Genética e Evolução, Instituto de Biologia, Universidade Estadual de Campinas Campinas 13083971, Brazil
*To whom correspondence should be addressed.
Summary: This report describes an algorithm (intensity-dependent selection of expression ratios or ISER) developed to analyse DNA array data by optimizing the selection of genes with the most significant variations in expression amongst two RNA samples. The algorithm is designed for use when little or no replication of array hybridizations is available.
Availability: ISER is written in R language, and its code and on-line version are freely available at https://ipe.cbmeg.unicamp.br/pub/PMmA
Contact: menossi{at}unicamp.br
Supplementary information: https://ipe.cbmeg.unicamp.br/pub/ISER
Received on May 25, 2005; revised on October 17, 2005; accepted on October 17, 2005