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Bioinformatics Advance Access originally published online on September 3, 2004
Bioinformatics 2005 21(3):405-407; doi:10.1093/bioinformatics/bti009
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Bioinformatics vol. 21 issue 3 © Oxford University Press 2005; all rights reserved.

easyLINKAGE: a PERL script for easy and automated two-/multi-point linkage analyses

Tom H. Lindner 1,2,* and K. Hoffmann 3

1 Division of Nephrology, Department of Medicine, Medical University Clinic at the University of Würzburg Würzburg, Germany
2 Department of Clinical Biochemistry and Pathobiochemistry, Medical University Clinic at the University of Würzburg Würzburg, Germany
3 Institute of Medical Genetics, Charité, Humboldt University Berlin Augustenburger Platz 1, 13353 Berlin, Germany

*To whom correspondence should be addressed.

Summary: We have generated the program easyLINKAGE that combines automated setup and performance of linkage analyses and simulation under an easy to handle graphical user interface for Microsoft Windows 2000/XP and standard UNIX systems. The program package supports two-point linkage analyses (FastLink v4.1 and SPLink v1.09), multi-point linkage analyses [GENEHUNTER v2.1, GENEHUNTER-PLUS with the emendation by Kong and Cox v1.2 (allele sharing modelling)] and the simulation package SLINK v2.65, and provides genome-wide as well as chromosomal postscript plots of LOD scores, NPL scores, P-values and other parameters.

Availability: http://www.uni-wuerzburg.de/nephrologie/molecular_genetics/molecular_genetics.htm

Contact: tom.lindner{at}mail.uni-wuerzburg.de

Supplementary information: Supplementary information is available on the website.


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