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Bioinformatics Advance Access originally published online on October 14, 2004
Bioinformatics 2005 21(6):699-702; doi:10.1093/bioinformatics/bti065
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Published by Oxford University Press 2004.

OCRE: a novel domain made of imperfect, aromatic-rich octamer repeats

Isabelle Callebaut * and Jean-Paul Mornon

Département de Biologie Structurale, LMCP, CNRS UMR7590, Universités Paris 6 & Paris 7 Case 115, 4 place Jussieu, 75252 Paris Cedex 05, France

*To whom correspondence should be addressed.

Summary: In this study, we describe a novel domain, OCRE, which is shared by the recently identified angiogenic factor VG5Q and a specific family of RNA-binding motif proteins.

The OCRE domain is characterized by a 5-fold, imperfectly repeated octameric sequence, which includes a triplet of often-conserved aromatic amino acids predicted to form a ß-strand and in which the slightly modified fifth repeat might act as a repeat terminator.

Although the function of this domain remains to be elucidated, the domain architecture of OCRE containing proteins and experimental data suggest a role in RNA metabolism and/or in signalling pathways activated by the tumor necrosis factor superfamily of cytokines.

Contact: Isabelle.Callebaut{at}lmcp.jussieu.fr


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